To determine if MYC is essential for hyperproliferative growth in the Ctdnep1-cKO tumor cells, we knocked down Myc utilizing a lentiviral shRNA and found that depletion of c-Myc strongly reduced the growth of Ctdnep1-cKO tumor cells (Fig. 5h), suggesting that tumor cell growth mediated by Ctdnep1-deficiency is dependent upon MYC levels. The gene discussed is MYC; the disease is neoplasm.