Intriguingly, all tumors from patients with CTDNEP1 mutations appeared to exhibit loss-of-heterozygosity (LOH) for the other allele of CTDNEP1. This suggests that CTDNEP1 may exhibit bi-allelic inactivation in patient tumors, which is typical of many tumor suppressors77,78. The gene discussed is CTDNEP1; the disease is neoplasm.