To further determine the potential role of the CTDNEP1 effectors in genomic stability, we examined the activities of candidate CTDNEP1 substrates such as mitotic regulators CDK1, a key cell-cycle regulator62, and SRPK1, a serine/arginine protein kinase important for mitosis, chromatin reorganization, and tumor growth63, by constructing the vectors expressing phospho-mimetics, SRPK1-S51D and CDK1-T14E/Y15D (CDK1-ED), given that Y15 phosphorylation was also identified in our phospho-proteomic analysis. The gene discussed is CDK1; the disease is neoplasm.