CTDNEP1 and Mobius syndrome: To further investigate how loss of Ctdnep1 drives gene expression profiles that underlie the development of aggressive MBs, we examined the genomic landscape and chromatin accessibility by performing ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing)38 and observed alterations in accessible chromatin sites in the absence of Ctdnep1 (Supplementary Fig. 9a).