Due to variable expression levels, we stratified the MB cohorts from publicly available datasets3,4,23 into patient populations with high and low CTDNEP1 expression across MB subgroups (Supplementary Fig. 3d), and found that lower CTDNEP1 expression level was correlated with significantly decreased overall survival in SHH-, G3- and G4-MB cohorts (Fig. 1f and Supplementary Fig. 3e), except for the WNT subgroup, although few CTDNEP1 mutations were present in SHH and G4 MBs. The gene discussed is CTDNEP1; the disease is Mobius syndrome.