MYC and neoplasm: To further confirm the Myc-locus-specific amplification, we performed whole genome sequencing (WGS) analysis and found that the Myc gene locus was amplified in late-stage Ctdnep1-cKO NPC and Ctdnep1-cKO-tumor cells, along with Trp53 gene loss-of-heterozygosity (Fig. 5k).