Dysregulation of the WNT and hedgehog (HH) pathway has been implicated in WNT and SHH subgroup tumors, respectively, while MYC-driven G3-MB, which comprises ~17% of G3-MBs, has the worst prognosis and is associated with amplification and overexpression of the c-MYC oncogene (MYC)1,5–8. This evidence concerns the gene SHH and Mobius syndrome.