In this study, by integrating analyses of newly diagnosed MBs and publicly available cohorts for recurrent genetic alterations, we found that CTDNEP1, encoding a CTD nuclear envelope-enriched phosphatase (a.k.a Dullard)19–21, is the most significantly mutated genes within G3-MBs compared with other MB subgroups4,14. The gene discussed is CTDNEP1; the disease is Mobius syndrome.