MYC and neoplasm: Principal component analysis showed that the gene profiles of Ctdnep1-cKO tumor cells had a closer relationship to those of murine MYC-driven G3-MB tumors from NPCs (e.g. Myc/Trp53−/− and Myc_Gfi1 MB models)12,13,34 than those from astrocyte progenitors (Sox2+ Myc model)35, SHH-MB tumors (e.g. SmoM2 OE and Ptch1 models)36,37 or normal cerebella (Fig. 4i).