In G3 MBs, we found that CTDNEP1 mutations significantly co-occurred with MYC amplification, copy number gains on Chr8p, Chr8q, Chr17q, and Chr1q, as well as the loss of Chr17p, while the mutually exclusive events included gain of Chr7p or Chr7p and loss of Chr16q or Chr10q (Fig. 1e and Supplementary Fig. 2c, d). Here, CTDNEP1 is linked to Mobius syndrome.