We observed loss-of-heterozygosity (LOH) of the other allele of CTDNEP1 on Chr17p in the majority of the G3 MBs carrying CTDNEP1 mutations (11 out of 12; Supplementary Fig. 2c–f), while LOH was not detected in the normal apparent peri-tumoral tissue in the same patient (Supplementary Fig. 2c). The gene discussed is CTDNEP1; the disease is Mobius syndrome.