For example, the low expression of HSP90B1 may inhibit antigen release of cancer cell, which causes immune cells failing to recognize tumor cells; The CXCL17 is highly expressed in all clusters and may induce the expression of VEGF, promoting tumor growth by increasing angiogenesis; the Th cells are recruited by the CCL20-CCR6 axis and then migrate into the TME, thereby resulting in the formation of immunosuppressive TME. The gene discussed is VEGFA; the disease is cancer.