In this case, we also found that 49.2% (95% CI = [48.6, 49.9]) of the participants would be selected by AD Course Map, versus 39.1% (95% CI = [38.7, 39.4]) for heterozygous APOE-ε4 carriers, facilitating recruitment with AD Course Map (see Supplementary Table 4). Here, APOE is linked to Alzheimer disease.