In 2021, Zhang et al. found that NAT10 could promote the metastasis of gastric cancer through ac4C acetylation of COL5A1 [17], and Wei Rongfang et al. found that NAT10 could regulate cell proliferation and cell cycle distribution through acetylation of CEP170mRNA in multiple myeloma and improve translation efficiency [26]. This evidence concerns the gene COL5A1 and plasma cell myeloma.