In HCC, loss of nucleolar localization of NAT10 promotes cell migration and invasion [27], and the up-regulation of NAT10 can promote the metastasis of HCC cells from epithelial cells to mesenchymal cells [28], enhance the doxorubicin resistance of human HCC cell lines [29], and also promote the metastasis of bladder cancer and laryngeal cancer cells. Here, NAT10 is linked to hepatocellular carcinoma.