TRAF4 and colorectal carcinoma: Ectopic overexpression of TRAF4 in TRAF4-knockout CRC cells restored the protein levels of Bcl-xL (Fig. 3F), as well as cell viability (Fig. 3G and S3A) and colony formation ability on plate or in soft agar (Fig. 3H and I, and S3B and C) even in the presence of irradiation.