Moreover, the ROS-responsive gene signature [genes upregulated by H2O2 (log2 FC > 2, adjusted p-value < 0.05); Table S5] determined from the transcriptome of H2O2-treated cancer cells (GSE32335) contains TIGAR and correlates positively with PARP1 transcription in MPM tumors (Fig. 6D, E). This evidence concerns the gene TIGAR and cancer.