PGD and cancer: For example, YTHDF2 was identified as a glioblastoma stem cell-specific m6A effector that promotes tumor growth by stabilizing MYC transcripts.40 In addition, YTHDF2 has been reported to promote HSP70, OCT4 and 6PGD mRNA translation and participate in cancer progression.20,41,42 Interestingly, our results support a similarly non-canonical function of m6A methylation.