POU5F1 and neoplasm: YTHDF2 promotes the liver cancer stem cell phenotype and metastasis through stabilizing m6A modification of OCT4 transcript.20 On the contrary, YTHDF2 also performs as a tumor suppressor and inhibits HCC growth by accelerating the degradation of EGFR transcript.26 Thus, the specific functions and potential mechanism of the m6A reader YTHDF2 in HCC require further exploration.