YTHDF2 promotes the liver cancer stem cell phenotype and metastasis through stabilizing m6A modification of OCT4 transcript.20 On the contrary, YTHDF2 also performs as a tumor suppressor and inhibits HCC growth by accelerating the degradation of EGFR transcript.26 Thus, the specific functions and potential mechanism of the m6A reader YTHDF2 in HCC require further exploration. This evidence concerns the gene YTHDF2 and hepatocellular carcinoma.