YTHDF2 and hepatocellular carcinoma: Moreover, MCM2/5 mRNAs levels, IHC staining and correlation analysis between YTHDF2 O-GlcNAcylation and MCM2/5 in clinical HBV-associated HCC tissues, proved that MCM2/5 were significantly upregulated with high expression of YTHDF2 and O-GlcNAcylation (Supplementary Fig. 9a–e).