We found that depletion of YTHDF2 greatly inhibited HCC growth, as reflected by the decrease in tumor volume, tumor weight, and immunohistochemical (IHC) staining of Ki67, which was recovered by re-expressing YTHDF2-WT but not YTHDF2-S263A (Fig. 4j–l and Supplementary Fig. 4f). Here, YTHDF2 is linked to hepatocellular carcinoma.