EPCAM and neoplasm: Surface proteins with homophilic adhesion domains, such as Thomsen-Friedenreich, E-cadherin, and epithelial cell adhesion molecules, are responsible for the multicellular aggregate formation, which can be reserved in Au@C-CCM.52 In our future research, we plan to sequence the tumor tissues of HNSCC patients, screen and investigate differentially expressed adhesion-related molecules or proteins that participate in homologous targeting, and stratify patients according to the expression level of these biomarkers.