In an attempt to explore the potential for NaHS in abrogating HD-like effects induced by 3-nitropropionic acid (3NP), a study in a rat HD model revealed that H2S improved overall cognitive and locomotor deficits whist provided antioxidant, anti-inflammatory and anti-apoptotic effects observed by reduced levels of oxidative stress marker malondialdehyde (MDA), TNF-α and caspase 3 activation [51]. The gene discussed is CASP3; the disease is Huntington disease.