Consistently, in a similar model of MPTP-induced PD in mice established by Lu et al., it was observed that NaHS reduced primary mesencephalic neurons cytotoxicity whilst explored molecular mechanism associated highlighting that H2S was able to enhance mitochondrial uncoupling protein 2 (UCP2) antioxidation resulting in abrogated ROS generation and reduced caspase 12-induced apoptosis [43]. This evidence concerns the gene UCP2 and Parkinson disease.