HIF1A and central nervous system cancer: An in vivo study reported by Li et al. showed that the size of the tumour was significantly increased in the rats exposed to NaHS in GBM group compared to the GBM only group, and H2S promotes C6 glioma cell growth via augmenting neurovascular formation and increasing hypoxia-inducible factor-1alpha (HIF-1α) expression [61].