In this regard, NaHS, has been observed to modulate inflammation by inhibiting the release of tumour necrosis factor- α (TNF-α) and reducing the expression of toll-like receptor 4 (TLR4), and NF-κB in the hippocampus of Sprague-Dawley rats subject to subarachnoid haemorrhage [38]. This evidence concerns the gene TLR4 and subarachnoid hemorrhage.