Univariate analysis revealed that sex, tumor depth, lymph node status, prior neoadjuvant therapy administration, αSMA and IL-6 expression, CD8+ (cytotoxic T-cells (CTL)) and FoxP3+ (regulatory T-cells (Treg)) TILs status, and CD163+ tumor-associated macrophages (TAMs; M2 macrophages) status were significant prognostic factors for OS (Table 1). The gene discussed is IL6; the disease is neoplasm.