In contrast, OE of SOD1-G93A, which is associated with ALS but not FTD, or OE of α-synuclein, which is associated with familial Parkinson’s disease (56), did not affect poly(GR) expression (Fig. 3A), demonstrating the specificity of FUS and TDP-43 effects on poly(GR) expression. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.