NR4A1 and psychiatric disorder: Despite the limitations presented by the highly polygenic nature of psychiatric disorders and the statistical price paid of testing millions of genetic variants in GWASs, we uncovered several genes of potential interest (table S2), including NR4A1, an important regulator of cocaine-induced gene regulation that plays an integral role in neuronal homeostasis and that has been linked to cocaine-evoked behaviors (17, 34, 35).