IL23R and hyperinsulinemic hypoglycemia, familial, 4: As a first approach to deciphering the cellular basis of MSMD and CMC in patients with inherited IL-23R deficiency, we compared the frequency of leukocyte subsets in the whole blood of healthy controls, five IL-23R-deficient patients, three IL-12Rβ1-deficient patients, and four patients heterozygous for STAT1 gain-of-function (GOF) variants (64), by CyTOF (Figure 3A and Figure S3A), and in peripheral blood mononuclear cells (PBMCs), by spectral flow cytometry (Figure S3B).