In light of the results of the CONFIRM trial and respiratory complications associated with the use of terlipressin combined with albumin, attention needs to be paid to potential pulmonary complications associated with higher vasopressor dosing.14 Notably, in addition to its vasopressor effect, norepinephrine has a cardiac inotropic effect15,16 that may reduce the risk of pulmonary edema, although conclusive data supporting such advantage are still lacking. The gene discussed is ALB; the disease is pulmonary edema.