Fibroblast growth factors (FGFs) facilitate a number of biological processes; Joki et al. injected FGF21 in a murine model post-MI and found that FGF21 exhibited anti-inflammatory properties (decreased TNF-α, IL-6), which attenuated remodeling and cardiomyocyte apoptosis while encouraging blood vessel formation [218]. This evidence concerns the gene FGF21 and myocardial infarction.