As illustrated in (Fig. 3), NLRP3, CASP1, and GSDMD mRNA expression levels were statistically significantly lower in different HCC grades (mild/moderately differentiated HCC “grade I-II” and poorly differentiated HCC “grade III”) and stages (early and late) than those levels observed in the control group (P < 0.001). This evidence concerns the gene NLRP3 and hepatocellular carcinoma.