PHA1a is an autosomal dominant disease, caused by dysfunctional or non-functioning mineralocorticoid receptor (MR) expression in the kidney, leading to renal aldosterone resistance, whereas PHA1b is an autosomal recessive disease, caused by defective epithelial sodium channel (EnaC) expression in different tissues, including salivary and sweat glands, lung, kidney, and colon, leading to systemic aldosterone resistance [69, 70]. This evidence concerns the gene NR3C2 and autosomal recessive disease.