APS-1 is a rare autosomal recessive disease, also known as autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), caused by variants in the autoimmune regulator gene (AIRE) [47], which is expressed in thymic medullary epithelial cells and dendritic cells. This evidence concerns the gene AIRE and autoimmune polyendocrine syndrome type 1.