This question was addressed, in part, after Glaeser and colleagues observed that, in colon adenocarcinoma samples, WNT3 expression positively correlates with Evi/Wls protein abundance but not with Evi/Wls mRNA expression, suggesting post-translational mechanisms adapt Evi/Wls to Wnt protein levels (Glaeser et al., 2018). The gene discussed is WLS; the disease is colon adenocarcinoma.