In a case report of a 22-year-old female with early-stage primary FSGS who failed to respond to intensive immunosuppressive therapy, Gineburg & Dau showed an immediate reduction of serum creatinine from 2.9 to 1.6 mg/dl and an increase in serum albumin from 3 to 3.7 g/dl after 1 week of PE, and a reduction of proteinuria by >50% from 8.8 to 2 g/day after 1 month of PE (total therapy consisted of once weekly for 2 months). The gene discussed is ALB; the disease is focal segmental glomerulosclerosis.