TF and infection: For this purpose, wehave set up a whole-cell, label-free MS proteomicsinvestigation on in vitro samples of THP-1 cellsinfected with Leishmania clinical isolatescharacterized by TF (four strains) and elective drug resistance (threestrains) to identify the most relevant proteins putatively involvedin drug resistance and/or TF after the infection of human host cells.THP-1 total proteomes were characterized by bottom-up LC-MS/MS sequencingand compared to the respective untreated/sensitive controls throughANOVA to evidence the differentially expressed proteins (DEPs).