TFRC and parasitic infectious disease: The transferrin receptor C (TFRC), also known as CD71, is anintegral membrane glycoprotein, ubiquitously expressed, consistingof two identical subunits linked by disulfide bridges. TFRC uptakesiron by endocytosis of the ligand-occupied transferrin and regulatesintracellular iron homeostasis.86 HumanTFRC has not been related to parasitic infections yet, but its contributionto iron metabolism suggests that - as for transferrin and lactoferrin- it could be employed by the parasite as a source of nutrient intake.