As demyelination is a hallmark of every aging brain (Muñoz Maniega et al., 2015), that over years has to withstand a continuous barrage of infections, inflammation and environmental irritants, we hypothesize that overactivation of TRPA1 may play some part in the typical demyelination occurring over our lifetimes, as well as during extensive demyelination in neurogenerative diseases. The gene discussed is TRPA1; the disease is infection.