TRPA1 is activated during periods of inflammation and oxidative stress (Bautista et al., 2013; Hamilton et al., 2016; Herrmann et al., 2019; Koivisto et al., 2014; Lennertz et al., 2012; Monteiro et al., 2020), and therefore it is important that we understand whether it plays a role in demyelinating and neurodegenerative diseases. Here, TRPA1 is linked to neurodegenerative disease.