SOX2 and cancer: Moreover, TA by itself has also been shown to exhibit a multitude of antitumor properties, including inhibition of the cancer cell proliferation, suppression of stemness by downregulating the protein expression of SOX2 and OCT4, and promotion of the G1 cell cycle arrest and induction of apoptosis, downregulation of the expression of AKT serine/threonine kinase 1 (AKT), among others [67–69].