Furthermore, Hassanzadeh et al. in 2012 showed the effectiveness of Ginkgo biloba on various neurotransmitters, such as increasing cerebral dopaminergic activity, 5HT1A and noradrenergic receptor reduction, reversible inhibition of MAO, A, and B, which has mild anti-anxiety and anti-depression effects in a systematic review on the usage of Ginko biloba plant in autism treatment [24]. This evidence concerns the gene HTR1A and major depressive disorder.