The increased proliferative capacity of tumors is due to alterations in the normal regulation of the cell cycle, and the contribution of HDAC4 to cell cycle progression has been observed in various contexts, including normal cells and different cancer models (Wilson et al., 2008; Feng et al., 2009; Cai et al., 2018; Bindea et al., 2009; Cao et al., 2019; Ha et al., 2022). The gene discussed is HDAC4; the disease is cancer.