The NPs specifically delivered siCXCL12 into CAFs by binding the FAP-α on the cell membrane of CAFs, knocked down the expression of CXCL12, resulting in the CAFs inactivation, the CAFs-related malignant TME remodeling and the inhibition of migration, invasion, metastasis, and tumor angiogenesis in vitro. Here, CXCL12 is linked to neoplasm.