Results showed that the combination of two NPs synergistically induced vascular normalization and remodeled TME in Panc-1 pancreatic cancer nude model and increased infiltration of CD4+ and CD8+ T cells in the B16-F10 melanoma model, providing a new direction for cancer therapy based on the tumor vasculature normalization and TME remodeling. The gene discussed is CD8A; the disease is neoplasm.