The modified peptide was mixed with T22-GFP-H6 to form self-assembly biparatopic nanoparticles by divalent cation coordination through histidine-rich regions (Lee et al., 2011), which showed a dramatically improved biodistribution in the mouse models of CXCR4+ human cancer, faster cell internalization and enhanced cell killing effect when compared to the version based on a single ligand. This evidence concerns the gene CXCR4 and cancer.