Based on it, a ß-Cyclodextrin (β-CD) modified matrix metalloproteinase-2 (MMP-2) responsive liposome (LRC-GEM-PFD) was constructed by a thin-film hydration method to regulate PSCs (Ji et al., 2016a), and RGD peptides were also modified onto the liposomes for targeting tumor cells. This evidence concerns the gene MMP2 and neoplasm.