In the AE and C-KITD816V mouse model, mPO-6 significantly reduced the percentage of AML cells infiltration and prolonged the median survival of AML mice by interfering CD123/IL-3 axis via regulating the activation of STAT5, PI3K/AKT, and NF-κB signaling pathways. This evidence concerns the gene NFKB1 and acute myeloid leukemia.