Through differential expression analysis, it was found that the expression of most m6A regulators was altered between the normal group and ischemic stroke patients; IGF2BP2, IGF2BP1, and YTHDF2 expression was significantly upregulated in IS samples, while ELAVL1, LRPPRC, METTL3, ALKBH5, CBLL1, and METTL14 expression was significantly downregulated in IS samples. The gene discussed is YTHDF2; the disease is ischemic stroke.