Through differential expression analysis, it was found that the expression of most m6A regulators was altered between the normal group and ischemic stroke patients; IGF2BP2, IGF2BP1, and YTHDF2 expression was significantly upregulated in IS samples, while ELAVL1, LRPPRC, METTL3, ALKBH5, CBLL1, and METTL14 expression was significantly downregulated in IS samples. Here, CBLL1 is linked to ischemic stroke.