Clinical studies have shown that the CD14+ CD16-and CD14+ CD16+ subpopulations of monocytes increase significantly between 0 and 16 days after the onset of IS, with an increase in the CD14+ CD16-subpopulation being closely associated with tissue damage in the acute and subacute phases of stroke (Kaito et al., 2013). The gene discussed is CD14; the disease is Stroke.