MAPT and Alzheimer disease: For example, in patients with Alzheimer’s disease, the abnormal accumulation of Aβ plaques and Tau tangles leads to neuronal cell death in the entorhinal cortex and hippocampus first, with plaques and tangles gradually being spread in the frontal lobe, parietal lobe, globus pallidus and other brain regions (Čaušević et al., 2010; Latimer et al., 2019).