Correlation analysis showed that ZBTB42 was positively related to PD1, PD-L1, PD-L2, CTLA4, TIM3, and LAG3 in LGG (Figure 5G) and positively related to PD-L1, PD-L2, SIRPA in GBM (Figure 5H), suggesting that the high expression of ZBTB42 may promote glioma progression via immune suppression microenvironment. The gene discussed is LAG3; the disease is central nervous system cancer.