Correlation analysis showed that ZBTB42 was positively related to PD1, PD-L1, PD-L2, CTLA4, TIM3, and LAG3 in LGG (Figure 5G) and positively related to PD-L1, PD-L2, SIRPA in GBM (Figure 5H), suggesting that the high expression of ZBTB42 may promote glioma progression via immune suppression microenvironment. This evidence concerns the gene PDCD1 and central nervous system cancer.