Correlation analysis showed that ZBTB42 was positively related to PD1, PD-L1, PD-L2, CTLA4, TIM3, and LAG3 in LGG (Figure 5G) and positively related to PD-L1, PD-L2, SIRPA in GBM (Figure 5H), suggesting that the high expression of ZBTB42 may promote glioma progression via immune suppression microenvironment. This evidence concerns the gene LAG3 and glioma.