Lactate secreted from hypoxic cancer cells also enters stalk ECs, where it enhances the expression of Gas6, VEGF, Ang-1, and IL-8, which act on their respective receptors present on stalk cells in an autocrine mechanism, activate Myc, cyclin-D1 genes and subsequently induce cell division in stalk ECs. This evidence concerns the gene CXCL8 and cancer.