TRAF7, an e3-ubiquitin ligase on the TNF-α/NF-κB pathway, can interact with the N-terminus of KLF4 protein to degrade it via ubiquitin, thereby eliminate the tumor-suppressor effect of KLF4 and enable cancer cell migration and invasion in vitro and vivo (24). The gene discussed is NFKB1; the disease is cancer.