Aberrant expression of several KLFs is strongly associated with tumorigenesis: KLF2 is a prognostic factor in HCC and BC (118, 204); KLF3 is low expressed in the peripheral blood of acute leukemia (205); KLF7 has been identified as an unfavorable prognostic marker in lung adenocarcinoma, gastric cancer, and high-grade plasma ovarian cancer (206, 207). The gene discussed is KLF2; the disease is hepatocellular carcinoma.