The evidence for urinary IL-6 and IL-8 is mirrored in a recent systematic review of febrile children with UTI; urinary IL-6 had a pooled sensitivity of 77% (95% CI 69%-83%) and specificity of 87% (95% CI 86%-92%), and urinary IL-8 had a pooled sensitivity of 87% (95% CI 82%-91%) and specificity of 90% (95% CI 87%-93%).63 The gene discussed is CXCL8; the disease is bacterial urinary tract infection.