Subsequent functional screens have proposed other synthetic lethal pairs, including the SWI/SNF chromatin remodeling complex membersSMARCA2-SMARCA4 (Hoffmanet al., 2014) andARID1A-ARID1B (Helminget al., 2014), as well as the Werner syndrome RecQ-like helicase (WRN) gene inMYC overexpressing cancers (Moseret al., 2012) and microsatellite unstable cancers (Chanet al., 2019;Kategayaet al., 2019;Liebet al., 2019). This evidence concerns the gene WRN and cancer.