AKT1 and cancer: AKT helps in metastasis and is associated with the aggressiveness of the tumor.36 AKT activation even inhibits the expression of proapoptotic proteins, such as BAD and BAX, and allows the cancer cells to survive.37,38 AKT can also inactivate the caspase enzymes, which are directly involved in cell apoptosis and forkhead box protein O1 (FOXO-1) expression.