In another study, triNbCAR‐T cells targeting CD33, CD123, and CLL1 tumor antigens could exhibit cytolytic activity equal to or greater than their monospecific counterparts and high levels of IFN-γ and IL-2 cytokines when exposed to CD33+ or CD123+ only tumors, whereas they produced lower levels of these cytokines when exposed to CLL+ only tumors (84). This evidence concerns the gene CD33 and B-cell chronic lymphocytic leukemia.