TLR2 and acne: Propionibacterium acnes induces an inflammatory response around the sebaceous glands leading to acne worsening mainly through the secretion of pro-inflammatory lipids and various cytokines, whereas MALP-2 upregulates sebocyte cells TLR-2 mRNA levels, stimulating the release of cytokines IL-6 and IL-8, thereby exacerbating the inflammatory response and acne worsening (41).