PROM1 and leukemia: In addition, researchers have designed CD22 CAR and CD133 CAR with either a short or long scFv linker, and found that the short scFv CAR (CART22-short or CD133 CAR-short) had excellent cytotoxicity, secreted more IFN-γ, IL2 and TNF-α, resulted in lower expression of exhaustion-associated surface proteins, exhibited significant anti-leukemia activity and improved animal survival.