In TMS patients during relapse, compared to those in remission, we observed a selective CD4+ T cell lymphopenia, with a lower abundance of two T cell subsets with Th2-like cell properties, referred here as Th-2 like-1 (HD versus TMS in relapse; adjusted p= 0.019) and T4 Th-2 like-4 (Kruskal Wallis H test, p= 0.047) (Figure 4C). The gene discussed is CD4; the disease is lymphopenia.