Subsequently, accumulative evidence has implied that the IGF2BP3 is post-transcriptionally active and plays a tumor-promoting role in various cancer types such as lung cancer (42), hepatocellular carcinoma (43), melanoma (44), and colorectal cancer (45), mainly by promoting tumor growth, invasion, metastasis, survival, and chemo-resistance (7–9). Here, IGF2BP3 is linked to hepatocellular carcinoma.