The results found that IGF2BP3 positively correlated with cell cycle and DNA damage in GBM; with metastasis in Astrocytoma; with metastasis, angiogenesis, quiescence, and differentiation in LUAD; with stemness and DNA damage in NSCLC; with angiogenesis, differentiation, and inflammation in RB; with invasion in AML. The gene discussed is IGF2BP3; the disease is retinoblastoma.