In view of our finding that PI3Kα, Akt and mTOR are conserved NET drivers across all stimuli tested, and given the role of NETs in awakening dormant cancer cells and promoting tumor invasion and distant metastases (49–53), it is conceivable that in cancer patients, inhibitors of PI3Kα, Akt and mTOR exert at least a part of their actions by interfering with NET formation. This evidence concerns the gene AKT1 and cancer.