STAT3 and acute respiratory distress syndrome: However, Feng D found that STAT3 had no effect after 6 h of APAP-induced ALI (88, 89) while Nishina T observed that STAT3 was still functional after 24 h; thus the specific relationship between APAP and STAT3 requires further investigation (90).The authors also reported that P-JAK2/P-STAT3 expression decreased after ischemia-reperfusion alone, which was inconsistent with previous results.