However, previous studies of Bregs have shown that in addition to IL-10, Bregs function is dependent on TGF-β and IL-35 (117), and IL-35 has been shown to be beneficial for ventricular remodeling after MI (118), yet whether Bregs acts through TGF-β and IL-35 after MI needs to be further explored. Here, TGFB1 is linked to myocardial infarction.