In our study, we analyzed the relationship between MAGs and the prognosis of patients with DLBCL in the GEO database and established a MAG prognostic model containing 14 genes (CCDC78, CD300LG, CTAG2, DYNLL2, MAPKAPK2, MREG, NME8, PGK2, RALBP1, SIGLEC1, SLC1A1, SLC39A12, TMEM63A, and WRAP73) that showed high predictive accuracy. The gene discussed is CCDC78; the disease is diffuse large B-cell lymphoma.