In our study, we analyzed the relationship between MAGs and the prognosis of patients with DLBCL in the GEO database and established a MAG prognostic model containing 14 genes (CCDC78, CD300LG, CTAG2, DYNLL2, MAPKAPK2, MREG, NME8, PGK2, RALBP1, SIGLEC1, SLC1A1, SLC39A12, TMEM63A, and WRAP73) that showed high predictive accuracy. This evidence concerns the gene NME8 and diffuse large B-cell lymphoma.