CD8A and hepatocellular carcinoma: It is reported that the subsets of immune cells such as tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), tumor-associated neutrophils (TANs), regulatory T cells (Tregs), cancer-associated fibroblasts (CAFs), CD8+ cytotoxic T lymphocytes (CTLs), and tumor-infiltrating lymphocytes (TILs) are critical immunosuppressive components in the TME of HCC, which could promote HCC growth and invasion [12].