Here, we chose acellular neural matrix (ACNM) as the carrier of calcitonin gene-related peptide II (CGRP II), which play an important role in chronic neuropathic pain, verifying the feasibility of the proposed method conceptually (Xie et al., 2017; Khan et al., 2019; de Vries et al., 2020). This evidence concerns the gene CALCB and Pain.