Exosomes can participate in regulating the function of trabecular meshwork cells, including involvement in transporting the glaucoma-associated secretory protein myocilin (Stamer et al., 2011), interfering with the classical Wnt signaling pathway (Tabak et al., 2018), regulating ECM turnover and remodeling (Dismuke et al., 2016), regulating atrial aqueous dynamics, thereby affecting intraocular pressure, thus participating in the development of glaucoma. Here, PROS1 is linked to glaucoma.