The mean serum chemerin was significantly higher in HD patients with DM (230.13 ± 78.26 ng/ml), followed by HD patients without DM (221.90 ± 65.17 ng/ml) compared with controls (110 ± 20.42 ng/ml). Also, the mean of serum chemerin significantly increased in DM patients (212.29 ± 70.88 ng/ml) when compared with the control. This evidence concerns the gene RARRES2 and Huntington disease.