Traits association analysis (Table 2) showed that SNPs (rs34665982, rs1582763, rs3740688, rs7412, rs1081105, rs12151021, rs147711004) of AD-related genes were associated with high cholesterol, coronary artery disease and multiple potential confounders (leukocytes, lymphocytes, neutrophil count, BMI, heel bone density, inflammatory bowel disease, hemoglobin concentration, apolipoprotein B, C-reactive protein, waist circumference, LDL, etc.). The gene discussed is APOB; the disease is Alzheimer disease.