Dengler-Crish et al. (2018) found that htau mice (an AD mouse model) had significantly lower BMD than C57BL/6 J mice, and htau mice exhibited inhibition of the Wnt/β-catenin signaling pathway in both the bone and brain. Guo et al. (2016) suggested that Dickkopf-related protein 1 (DKK1), a key endogenous antagonist of the Wnt signaling pathway, may be a common risk molecule for AD and osteoporosis. Recent studies have proposed new mechanisms for the correlation between osteoporosis and AD (Jiang et al., 2022). This evidence concerns the gene DKK1 and Alzheimer disease.