PTK2B and early-onset autosomal dominant Alzheimer disease: Osteoporosis and Alzheimer’s disease may share genetic and biological mechanisms, such as impaired cellular energy due to the effects of AKT (a serine–threonine kinase that is also known as protein kinase B, or PKB) on glucose uptake or defects in Wnt/β-linked protein signaling (Dengler-Crish and Elefteriou, 2019; Fehsel and Christl, 2022).