In a recent study, researchers analyzed the subpopulations of M1 (CD68 and iNOS) and M2 (CD68 and CD206) macrophage polarization through Immunofluorescence staining, noting a statistically significant increase in population of macrophage M1 phenotype from peri-implantitis samples compared to periodontal disease samples. Here, MRC1 is linked to periodontal disorder.