VHL and neoplasm: Knocking down HIF-1α negative regulator von Hippel-Lindau (VHL) in CD8+ T cells led to differentiation of tissue-resident memory-like (Trm-like) tumor-infiltrating lymphocyte (TIL), by which VHL-/- TILs accumulated in tumors and showed a core Trm signature, indicating that HIF-1α activity in CD8+ TILs up-regulates accumulation and antitumor activity (113).