GENEMANIA analysis showed that the TGF-β/SMAD signaling pathway was a significantly altered signaling pathway (Supplementary Figure 1C), and some metabolic disorders and immune disease-related processes were significantly enriched according to the DisGeNET analysis, such as hyperinsulinism, scleroderma, juvenile arthritis, inflammation, and celiac disease (Figure 3C). Here, TGFB1 is linked to metabolic disease.