GENEMANIA analysis showed that the TGF-β/SMAD signaling pathway was a significantly altered signaling pathway (Supplementary Figure 1C), and some metabolic disorders and immune disease-related processes were significantly enriched according to the DisGeNET analysis, such as hyperinsulinism, scleroderma, juvenile arthritis, inflammation, and celiac disease (Figure 3C). This evidence concerns the gene TGFB1 and Other metabolic disease.